Covid-19 vaccination programme effectiveness against SARS-CoV-2 related infections, hospital admissions and deaths in the Apulia region of Italy: a one-year retrospective cohort studyArticle Published on 2022-11-032022-11-16 Journal: Scientific Reports [Category] SARS, 변종, [키워드] Ad26.COV2.S vaccine Alpha Apulia calculate ChAdOx1-S Cohort combined use conducted COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccination programme Cox regression model death deaths Delta variants dominant Effect Effectiveness Effects Electronic health record eligible estimate hazard ratio Hospital admission hospitalisation infections Italy mRNA-1273 of BNT162b2 Older outcome positive Protective reduced retrospective cohort study SARS-CoV-2 SARS-CoV-2 infections study period subject vaccination Vaccine variant variants waned were used yielding [DOI] 10.1038/s41598-022-23235-4 PMC 바로가기
RASCL: Rapid Assessment of Selection in CLades through molecular sequence analysisArticle Published on 2022-11-022022-11-16 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] acting Analysis assessment automatically COVID-19 pandemic dataset datasets detect evaluate Evolution Genome Genome sequences genomes genomic include Intensive Lineage lineages molecular Mutation natural selection Notation object pathogen Phylogenetic Rapid SARS-CoV-2 selected Selection selective sensitivity sequence Sequence analysis sequencing error Surveillance underlie unmet need variants of concern whole genes yielding [DOI] 10.1371/journal.pone.0275623 PMC 바로가기
Estimation of R0 for the spread of SARS-CoV-2 in Germany from excess mortalityArticle Published on 2022-10-142022-11-16 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI calculated can be used contagious dataset death deaths determine early phase Effect estimate estimation Europe Germany growth growth factor incidence Infection lockdown measure Mortality much higher much lower office pandemic performed Robert Koch RT-PCR RT-PCR test RT-PCR testing SARS-CoV-2 Spread subject thought used data variant yielding [DOI] 10.1038/s41598-022-22101-7 PMC 바로가기
Development of a high-sensitivity and short-duration fluorescence in situ hybridization method for viral mRNA detection in HEK 293T cellsArticle Published on 2022-10-042022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition antibody Antigen applied approach Blood caused Cell Cell culture cells Concentration contagious coronavirus Coronavirus disease 2019 COVID-19 development Diagnosis disease DNA virus effective false-negative False-positive results faster Fluorescence in situ hybridization gold standard HEK 293T HEK 293T cell hepatitis A virus HPV Human immunodeficiency virus human papillomavirus IgM and IgG IMPROVE influenza viruses limitation MERS-CoV Middle East Monkeypox mRNA mRNA. patients plasmids probe Protein public health reduced respiratory syndrome coronavirus RNA RNA virus RNA virus RT-PCR SARS-CoV-2 SARS-CoV-2 detection SARS-CoV-2 viral Sensitivity and specificity significantly spike Surveillance tissue Treatment virus was increased yielding [DOI] 10.3389/fcimb.2022.960938 PMC 바로가기
Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질을 표적으로 하는 네이티브, 엔지니어링 및 드노보 디자인 리간드Review Published on 2022-10-012022-09-12 Journal: Biotechnology advances [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome affinity Affinity ligands antibody binding Cell concerning Contact coronavirus coronavirus disease de novo de novo design. develop diagnostic diagnostics hACE2 Host human Angiotensin-converting enzyme in vivo infect Interaction lesson Ligand ligands molecular Native natural pandemic Pandemics Patient Prophylactic Protein public health receptor reported responsible S-protein SARS-CoV-2 SARS-CoV-2 proteins Scientific community spike Spike protein the SARS-CoV-2 therapeutic therapy Vaccine virus yielding [DOI] 10.1016/j.biotechadv.2022.107986 PMC 바로가기 [Article Type] Review
Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virionsArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] 6-Thioguanine ACE2-expressing cells acting antiviral activity antiviral drug antivirals approach betacoronavirus betacoronaviruses biochemical Cell complementary coronavirus demonstrated early stage ectopic expression Effect full-length Genetic GTPase had no HCoV-OC43 HPRT1 in vitro infect Infection inhibit inhibitor lentivirus nucleotide oligosaccharide outcome progeny virion Protein pseudotyped pseudovirus Replication SARS-CoV-2 selective shown spike structural proteins subgenomic RNA target Treatment Viral diseases viral genomes Virus-like particle VLPs yielding [DOI] 10.1371/journal.ppat.1010832 PMC 바로가기
Quantifying the Relationship between SARS-CoV-2 Wastewater Concentrations and Building-Level COVID-19 Prevalence at an Isolation Residence: A Passive Sampling ApproachArticle Published on 2022-09-072022-11-15 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, 치료제, [키워드] approach association baseline collected college campus monitoring complex concentrations correlated covariate COVID-19 demonstrated Epidemiology excreta fecal Fecal shedding help highlight individuals with COVID-19 Infection infections Isolation Laboratory maintain majority median MONITOR multivariable model N1 and N2 Passive Passive sampling polymerase chain positive correlation Prevalence processed public health Public health responses quantified Quantitative relationship remained RNA load RT-qPCR Sample sampling SARS-CoV-2 SARS-CoV-2 RNA specimen Surveillance susceptible the mean Variation Viral load viral shedding wastewater Wastewater-based epidemiology. yielding [DOI] 10.3390/ijerph191811245 PMC 바로가기
SARS-CoV-2 transmission from infected owner to household dogs and cats is associated with food sharingArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Active surveillance addition animal anthropogenic association cats collected coronavirus country COVID-19 COVID-19 pandemic dogs Ecuador food Food sharing gene target IMPROVE Interaction Latin Latin America nasal swab oral ORF1ab organization pets polymerase chain positive Quantitative reported reverse transcription risk factor Risk factors risk of transmission SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 surveillance SARS-CoV-2 test SARS-CoV-2 transmission SARS-CoV-2. Sequencing shown Spread statistically significant Support tested Total Transmission transmission of SARS-CoV-2 was performed whole genome yielding [DOI] 10.1016/j.ijid.2022.05.049 PMC 바로가기
Measles incidence in South Africa: a six-year review, 2015-2020Article Published on 2022-08-302022-11-15 Journal: BMC Public Health [Category] 진단, [키워드] affected age confirmed cases country Coverage COVID-19 Decline defined Effectiveness effort Elimination enhanced Epidemiology excluded febrile FIVE incidence incidence rate less lockdown restrictions Measle meet molecular outbreak Outbreaks positive Rash receive Region required retrospective South South Africa specimen Surveillance surveillance data targets tested the vaccine vaccination Vaccine vaccine. Vaccines WHO World Health Organization yielding [DOI] 10.1186/s12889-022-14069-w PMC 바로가기
Lowered Quality of Life in Long COVID Is Predicted by Affective Symptoms, Chronic Fatigue Syndrome, Inflammation and Neuroimmunotoxic Pathways긴 COVID에서 삶의 질 저하가 정동 증상, 만성 피로 증후군, 염증 및 신경 면역 독성 경로에 의해 예측됩니다Article Published on 2022-08-192022-09-11 Journal: International Journal of Environmental Research an [Category] 바이오마커, [키워드] Activation acute infection Affect Anxiety AstraZeneca Biomarker body temperature calcium caspase caspase-1 chronic chronic fatigue syndrome controls COVID COVID-19 Depression domain Effect explained fatigue fatigue syndrome female fibromyalgia Health Organization IL-18 immune Inflammation inflammatory biomarkers insulin insulin resistance life Long Long COVID Myalgic encephalomyelitis/chronic fatigue syndrome myeloperoxidase neuro-immune neurotoxicity oxidative stress oxygen oxygen saturation participant pathway Pfizer physical predicted Protein psychiatry Psychiatry. Psychological Quality Quality of life rating scales recruited Regression serum severity Sex SpO2 subsequent Switzerland vaccination variance Version World Health Organization yielding [DOI] 10.3390/ijerph191610362 PMC 바로가기 [Article Type] Article